CDC revises flu treatment guidance

The CDC issued an article on the 14^th of Dec. 2009 with revision of the guidelines for the treatment of swine flu with Tamiflu and states that:

1- Patients with mild, uncomplicated illness who are not considered to be at increased risk of developing severe or complicated illness are not likely to benefit from antiviral treatment if started more than 48 hours after illness onset

2- Antiviral regimens lasting 5 days are recommended for patients with confirmed or suspected 2009 H1N1 influenza who have severe, complicated, or progressive illness, or who are hospitalized ( This may extend for some patients)

3- Promptly begin empiric antiviral therapy for patients with confirmed or suspected influenza who have an increased risk for complications (include children younger than 2 years old, adults aged 65 years and older, pregnant women, and individuals with certain medical conditions)

4- Available data suggest pregnant women should receive prompt antiviral therapy (no clinical studies have assessed the safety and efficacy of Oseltamivir (Tamiflu) or Zanamivir (Relenza) for pregnant women), also the agency advises prompt antiviral treatment of women up to 2 weeks postpartum with suspected or confirmed 2009 H1N1 influenza (because reports have suggested that they also may be at risk for severe complications and death)

The CDC also updated its recommendations for dosing oseltamivir to pediatric patients

1- For treatment purposes, infants younger than 1 year old should receive 3 mg/kg of the drug twice per day

2- For chemoprophylaxis, those aged 3 months to less than 1 year should receive 3 mg/kg oseltamivir once per day

3- Although oseltamivir dosing by weight is preferred for full-term infants younger than 1 year, it can be given according to age for treatment: 12 mg at 0-3 months, 20 mg at 3-5 months, and 25 mg at 6-11 months. Those doses should be halved for prophylaxis.

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